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1

Targeting Endocannabinoid Signaling: FAAH and MAG Lipase Inhibitors

Egmond, NoÃ«lle van, Straub, Verena M., der Stelt, Mario van

Journal:

Annual Review of Pharmacology

Year:

2021

File:

PDF, 1.04 MB

2021

2

Acute neuronal injury, excitotoxicity, and the endocannabinoid system

Mario van der Stelt, Wouter B. Veldhuis, Mauro Maccarrone, Peter R. Bär, Klaas Nicolay, Gerrit A. Veldink, Vincenzo Di Marzo, Johannes F. G. Vliegenthart

Journal:

Molecular Neurobiology

Year:

2002

Language:

english

File:

PDF, 310 KB

english, 2002

3

Comprehensive Analysis of Structure–Activity Relationships of α-Ketoheterocycles as sn -1-Diacylglycerol Lipase α Inhibitors

Janssen, Freek J., Baggelaar, Marc P., Hummel, Jessica J. A., Overkleeft, Herman S., Cravatt, Benjamin F., Boger, Dale L., van der Stelt, Mario

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 1.12 MB

english, 2015

4

Development of a Cannabinoid-Based Photoaffinity Probe to Determine the Δ 8/9 -Tetrahydrocannabinol Protein Interaction Landscape in Neuroblastoma Cells

Soethoudt, Marjolein, Alachouzos, Georgios, van Rooden, Eva J., Moya-Garzón, María Dolores, van den Berg, Richard J.B.H.N., Heitman, Laura H., van der Stelt, Mario

Journal:

Cannabis and Cannabinoid Research

Year:

2018

Language:

english

File:

PDF, 1.32 MB

english, 2018

5

Drug Discovery Maps, a machine learning model, visualizes and predicts kinome-inhibitor interaction landscapes

Janssen, Antonius P.A., Grimm, Sebastian H., Wijdeven, Ruud H.M., Lenselink, Eelke B., Neefjes, Jacques, van Boeckel, Constant C.A., van Westen, Gerard J.P., van der Stelt, Mario

Journal:

Journal of Chemical Information and Modeling

Year:

2018

Language:

english

File:

PDF, 7.49 MB

english, 2018

6

Endovanilloids : Putative endogenous ligands of transient receptor potential vanilloid 1 channels

Mario van der Stelt, Vincenzo Di Marzo

Journal:

Year:

2004

Language:

english

File:

PDF, 240 KB

english, 2004

7

Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels

van der Stelt, Mario, Trevisani, Marcello, Vellani, Vittorio, De Petrocellis, Luciano, Schiano Moriello, Aniello, Campi, Barbara, McNaughton, Peter, Geppetti, Piero, Di Marzo, Vincenzo

Journal:

The EMBO Journal

Year:

2005

Language:

english

File:

PDF, 277 KB

english, 2005

8

Cannabinoid receptors and their role in neuroprotection

Mario van der Stelt, Vincenzo Di Marzo

Journal:

NeuroMolecular Medicine

Year:

2005

Language:

english

File:

PDF, 197 KB

english, 2005

9

Discovery and Optimization of 1-(4-(Pyridin-2-yl)benzyl)imidazolidine-2,4-dione Derivatives As a Novel Class of Selective Cannabinoid CB2 Receptor Agonists

van der Stelt, Mario, Cals, Jos, Broeders-Josten, Silvia, Cottney, Jean, van der Doelen, Antoon A., Hermkens, Marcel, de Kimpe, Vera, King, Angela, Klomp, Jan, Oosterom, Julia

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 1.16 MB

english, 2011

10

The endocannabinoid system in the basal ganglia and in the mesolimbic reward system: implications for neurological and psychiatric disorders

Mario van der Stelt, Vincenzo Di Marzo

Journal:

European Journal of Pharmacology

Year:

2003

Language:

english

File:

PDF, 330 KB

english, 2003

11

Anandamide as an intracellular messenger regulating ion channel activity

Mario van der Stelt, Vincenzo Di Marzo

Journal:

Prostaglandins and Other Lipid Mediators

Year:

2005

Language:

english

File:

PDF, 98 KB

english, 2005

12

The role of the CB1 cannabinoid receptor and its endogenous ligands, anandamide and 2-arachidonoylglycerol, in amphetamine-induced behavioural sensitization

Gunnar Thiemann, Mario van der Stelt, Stefania Petrosino, Areles Molleman, Vincenzo Di Marzo, Rüdiger U. Hasenöhrl

Journal:

Behavioural Brain Research

Year:

2008

Language:

english

File:

PDF, 258 KB

english, 2008

13

Biosynthesis of endocannabinoids and their modes of action in neurodegenerative diseases

Mario van der Stelt, Henrik H. Hansen, Wouter B. Veldhuis, Peter R. Bär, Klaas Nicolay, Gerrit A. Veldink, Johannes F. G. Vliegenthart, Harald S. Hansen

Journal:

Neurotoxicity Research

Year:

2003

Language:

english

File:

PDF, 1.52 MB

english, 2003

14

Oxygenated Metabolites of Anandamide and 2-Arachidonoylglycerol: Conformational Analysis and Interaction with Cannabinoid Receptors, Membrane Transporter, and Fatty Acid Amide Hydrolase

van der Stelt, Mario, van Kuik, J. Albert, Bari, Monica, van Zadelhoff, Guus, Leeflang, Bas R., Veldink, Gerrit A., Finazzi-Agrò, Alessandro, Vliegenthart, Johannes F. G., Maccarrone, Mauro

Journal:

Journal of Medicinal Chemistry

Year:

2002

Language:

english

File:

PDF, 276 KB

english, 2002

15

N-Arachidonoyl-Dopamine Tunes Synaptic Transmission onto Dopaminergic Neurons by Activating both Cannabinoid and Vanilloid Receptors

Marinelli, Silvia, Di Marzo, Vincenzo, Florenzano, Fulvio, Fezza, Filomena, Viscomi, Maria Teresa, van der Stelt, Mario, Bernardi, Giorgio, Molinari, Marco, Maccarrone, Mauro, Mercuri, Nicola B

Journal:

Neuropsychopharmacology

Year:

2007

Language:

english

File:

PDF, 465 KB

english, 2007

16

Structure-Based Design of β1i or β5i Specific Inhibitors of Human Immunoproteasomes

de Bruin, Gerjan, Huber, Eva M., Xin, Bo-Tao, van Rooden, Eva J., Al-Ayed, Karol, Kim, Kyung-Bo, Kisselev, Alexei F., Driessen, Christoph, van der Stelt, Mario, van der Marel, Gijsbert A., Groll, Mich

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 2.76 MB

english, 2014

17

N -Tetradecylcarbamyl Lipopeptides as Novel Agonists for Toll-like Receptor 2

Willems, Marian M. J. H. P., Zom, Gijs G., Khan, Selina, Meeuwenoord, Nico, Melief, Cornelis J. M., van der Stelt, Mario, Overkleeft, Herman S., Codée, Jeroen D. C., van der Marel, Gijsbert A., Ossend

Journal:

Journal of Medicinal Chemistry

Year:

2014

Language:

english

File:

PDF, 547 KB

english, 2014

18

Peripherally Restricted, Selective Cannabinoid CB2 Receptor Agonist LEI-101 Prevents Cisplatin-Induced Nephrotoxicity by Attenuating Oxidative/Nitrative Stress and Inflammation

Mukhopadhyay, Partha, Holovac, Eileen, Erdelyi, Katalin, Cinar, Resat, Kunos, George, van der Stelt, Mario, Pacher, Pal

Journal:

Free Radical Biology and Medicine

Year:

2014

Language:

english

File:

PDF, 99 KB

english, 2014

19

Development of an acid ceramidase activity-based probe

Ouairy, Cécile M. J., Ferraz, Maria J., Boot, Rolf G., Baggelaar, Marc P., van der Stelt, Mario, Appelman, Monique, van der Marel, Gijsbert A., Florea, Bogdan I., Aerts, Johannes M. F. G., Overkleeft,

Journal:

Chemical Communications

Year:

2015

Language:

english

File:

PDF, 1.51 MB

english, 2015

20

Direct and two-step bioorthogonal probes for Bruton's tyrosine kinase based on ibrutinib: a comparative study

Liu, Nora, Hoogendoorn, Sascha, van de Kar, Bas, Kaptein, Allard, Barf, Tjeerd, Driessen, Christoph, Filippov, Dmitri V., van der Marel, Gijsbert A., van der Stelt, Mario, Overkleeft, Herman S.

Journal:

Organic & Biomolecular Chemistry

Year:

2015

Language:

english

File:

PDF, 1.20 MB

english, 2015

21

Cyclopentitol as a scaffold for a natural product-like compound library for drug discovery

Padwal, Jalindar D., Filippov, Dmitri V., Narhe, Bharat D., Aertssen, Sjoerd, Beuving, Remmelt Jan, Benningshof, Jorg C.J., van der Marel, Gijsbert A., Overkleeft, Herman S., van der Stelt, Mario

Journal:

Bioorganic & Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 2.00 MB

english, 2015

22

A natural substrate-based fluorescence assay for inhibitor screening on diacylglycerol lipase α

van der Wel, Tom, Janssen, Freek J., Baggelaar, Marc P., Deng, Hui, den Dulk, Hans, Overkleeft, Herman S., van der Stelt, Mario

Journal:

The Journal of Lipid Research

Year:

2015

Language:

english

File:

PDF, 1.08 MB

english, 2015

23

Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action

Ost, Mario, Coleman, Verena, Voigt, Anja, van Schothorst, Evert M., Keipert, Susanne, van der Stelt, Inge, Ringel, Sebastian, Graja, Antonia, Ambrosi, Thomas, Kipp, Anna P., Jastroch, Martin, Schulz,

Journal:

Molecular Metabolism

Year:

2016

Language:

english

File:

PDF, 4.62 MB

english, 2016

24

Photo-crosslinking of clinically relevant kinases using H89-derived photo-affinity probes

Stolze, Sara C., Liu, Nora, Wijdeven, Ruud H., Tuin, Adriaan W., van den Nieuwendijk, Adrianus M. C. H., Florea, Bogdan I., van der Stelt, Mario, van der Marel, Gijsbert A., Neefjes, Jacques J., Overk

Journal:

Molecular BioSystems

Year:

2016

Language:

english

File:

PDF, 2.54 MB

english, 2016

25

A Set of Activity-Based Probes to Visualize Human (Immuno)proteasome Activities

de Bruin, Gerjan, Xin, Bo Tao, Kraus, Marianne, van der Stelt, Mario, van der Marel, Gijsbert A., Kisselev, Alexei F., Driessen, Christoph, Florea, Bogdan I., Overkleeft, Herman S.

Journal:

Angewandte Chemie International Edition

Year:

2016

Language:

english

File:

PDF, 4.42 MB

english, 2016

26

A Set of Activity-Based Probes to Visualize Human (Immuno)proteasome Activities

de Bruin, Gerjan, Xin, Bo Tao, Kraus, Marianne, van der Stelt, Mario, van der Marel, Gijsbert A., Kisselev, Alexei F., Driessen, Christoph, Florea, Bogdan I., Overkleeft, Herman S.

Journal:

Angewandte Chemie

Year:

2016

Language:

english

File:

PDF, 4.39 MB

english, 2016

27

Inhibitors of diacylglycerol lipases in neurodegenerative and metabolic disorders

Janssen, Freek J., van der Stelt, Mario

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2016

Language:

english

File:

PDF, 543 KB

english, 2016

28

Structure-Based Design of β5c Selective Inhibitors of Human Constitutive Proteasomes

Xin, Bo-Tao, de Bruin, Gerjan, Huber, Eva M., Besse, Andrej, Florea, Bogdan I., Filippov, Dmitri V., van der Marel, Gijsbert A., Kisselev, Alexei F., van der Stelt, Mario, Driessen, Christoph, Groll,

Journal:

Journal of Medicinal Chemistry

Year:

2016

Language:

english

File:

PDF, 973 KB

english, 2016

29

Further evidence for the existence of a specific process for the membrane transport of anandamide

LIGRESTI, Alessia, MORERA, Enrico, van der STELT, Mario, MONORY, Krisztina, LUTZ, Beat, ORTAR, Giorgio, Di MARZO, Vincenzo

Journal:

Biochemical Journal

Year:

2004

Language:

english

File:

PDF, 218 KB

english, 2004

30

Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action

Coleman, Verena, Ost, Mario, Voigt, Anja, van Schothorst, Evert M., Keipert, Susanne, van der Stelt, Inge, Ringel, Sebastian, Graja, Antonia, Ambrosi, Thomas, Kipp, Anna P., Jastroch, Martin, Schulz,

Journal:

Mammalian Biology - Zeitschrift für Säugetierkunde

Year:

2016

Language:

english

File:

PDF, 62 KB

english, 2016

31

Quantitative profiling of endocannabinoids and related N -acylethanolamines in human CSF using nano LC-MS/MS

Kantae, Vasudev, Ogino, Shinji, Noga, Marek, Harms, Amy C., van Dongen, Robin M., Onderwater, Gerrit L. J., van den Maagdenberg, Arn M. J. M., Terwindt, Gisela M., van der Stelt, Mario, Ferrari, Miche

Journal:

The Journal of Lipid Research

Year:

2017

Language:

english

File:

PDF, 1.15 MB

english, 2017

32

Chemical Proteomics Maps Brain Region Specific Activity of Endocannabinoid Hydrolases

Baggelaar, Marc P., van Esbroeck, Annelot C. M., van Rooden, Eva J., Florea, Bogdan I., Overkleeft, Herman S., Marsicano, Giovanni, Chaouloff, Francis, van der Stelt, Mario

Journal:

ACS Chemical Biology

Year:

2017

Language:

english

File:

PDF, 2.08 MB

english, 2017

33

Chiral disubstituted piperidinyl ureas: a class of dual diacylglycerol lipase-α and ABHD6 inhibitors

Deng, Hui, van der Wel, Tom, van den Berg, Richard J. B. H. N., van den Nieuwendijk, Adrianus M. C. H., Janssen, Freek J., Baggelaar, Marc P., Overkleeft, Hermen S., van der Stelt, Mario

Journal:

Year:

2017

Language:

english

File:

PDF, 1.06 MB

english, 2017

34

Chemical tools to modulate 2-AG biosynthesis

Deng, Hui, van der Stelt, Mario

Journal:

Biotechnology and Applied Biochemistry

Year:

2017

Language:

english

File:

PDF, 1.15 MB

english, 2017

35

Piperidine and octahydropyrano[3,4- c ] pyridine scaffolds for drug-like molecular libraries of the European Lead Factory

Narhe, Bharat D., Breman, Arjen C., Padwal, Jalindar, Vandenput, Dirk A.L., Scheidt, Joeri M., Benningshof, Jorg C.J., van der Marel, Gijsbert A., Overkleeft, Herman S., van der Stelt, Mario, Filippov

Journal:

Bioorganic & Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 743 KB

english, 2017

36

A novel selective inverse agonist of the CB2 receptor as a radiolabeled tool compound for kinetic binding studies

Martella, Andrea, Sijben, Huub, Rufer, Arne, Fingerle, Juergen, Grether, Uwe, Ullmer, Christoph, Hartung, Thomas, IJzerman, Ad, van der Stelt, Mario, Heitman, Laura

Journal:

Molecular Pharmacology

Year:

2017

Language:

english

File:

PDF, 1.57 MB

english, 2017

37

Novel activity-based probes for N-acylethanolamine acid amidase

Petracca, Rita, romeo, elisa, baggelaar, Marc, Artola, Marta, Pontis, Silvia, Ponzano, Stefano, Overkleeft, Hermen, van der Stelt, Mario, Piomelli, Daniele

Journal:

Chemical Communications

Year:

2017

Language:

english

File:

PDF, 1.20 MB

english, 2017

38

The endocannabinoid system and its therapeutic exploitation in multiple sclerosis: Clues for other neuroinflammatory diseases

Chiurchiù, Valerio, van der Stelt, Mario, Centonze, Diego, Maccarrone, Mauro

Journal:

Progress in Neurobiology

Year:

2017

Language:

english

File:

PDF, 2.74 MB

english, 2017

39

Evaluation of different drug classes on transient sciatic nerve injury-depressed marble burying in mice

Wilkerson, Jenny L, Curry, Zachary A, Kinlow, Pamela D, Mason, Brittany L, Hsu, Ku-Lung, van der Stelt, Mario, Cravatt, Benjamin F, Lichtman, Aron H

Journal:

Year:

2018

Language:

english

File:

PDF, 2.33 MB

english, 2018

40

Structure-kinetic relationship studies of cannabinoid CB 2 receptor agonists reveal substituent-specific lipophilic effects on residence time

Soethoudt, Marjolein, Hoorens, Mark W.H., Doelman, Ward, Martella, Andrea, van der Stelt, Mario, Heitman, Laura H.

Journal:

Biochemical Pharmacology

Year:

2018

Language:

english

File:

PDF, 931 KB

english, 2018

41

Mapping in vivo target interaction profiles of covalent inhibitors using chemical proteomics with label-free quantification

van Rooden, Eva J, Florea, Bogdan I, Deng, Hui, Baggelaar, Marc P, van Esbroeck, Annelot C M, Zhou, Juan, Overkleeft, Herman S, van der Stelt, Mario

Journal:

Nature Protocols

Year:

2018

Language:

english

File:

PDF, 523 KB

english, 2018

42

Regulation of Adipose Tissue Metabolism by the Endocannabinoid System

van Eenige, Robin, van der Stelt, Mario, Rensen, Patrick C.N., Kooijman, Sander

Journal:

Trends in Endocrinology & Metabolism

Year:

2018

Language:

english

File:

PDF, 1.56 MB

english, 2018

43

2-Arachidonoylglycerol: A signaling lipid with manifold actions in the brain

Baggelaar, Marc P., Maccarrone, Mauro, van der Stelt, Mario

Journal:

Progress in Lipid Research

Year:

2018

Language:

english

File:

PDF, 933 KB

english, 2018

44

Discovery of Novel Small Molecule Activators of β-Catenin Signaling

Verkaar, Folkert, van der Stelt, Mario, Blankesteijn, W. Matthijs, van der Doelen, Antoon A., Zaman, Guido J. R., Gottardi, Cara

Journal:

Year:

2011

Language:

english

File:

PDF, 425 KB

english, 2011

45

Two-step activity-based protein profiling of diacylglycerol lipase

van Rooden, Eva J., Kreekel, Roy, Hansen, Thomas, Janssen, Antonius P. A., van Esbroeck, Annelot C. M., den Dulk, Hans, van den Berg, Richard J. B. H. N., Codée, Jeroen D. C., van der Stelt, Mario

Journal:

Organic & Biomolecular Chemistry

Year:

2018

Language:

english

File:

PDF, 816 KB

english, 2018

46

Gene Expression of Endocannabinoid System Components in Skeletal Muscle and Adipose Tissue of South Asians and White Caucasians with Overweight

Nahon, Kimberly J., Kantae, Vasudev, den Haan, Roy, Hanssen, Mark J.W., Harms, Amy C., van der Stelt, Mario, Hankemeier, Thomas, Jazet, Ingrid M., van Marken Lichtenbelt, Wouter D., Rensen, Patrick C.

Journal:

Year:

2018

Language:

english

File:

PDF, 206 KB

english, 2018

47

An Affinity-based Probe for the human Adenosine A 2A Receptor

Yang, Xue, Michiels, Thomas J.M., de Jong, Coen, Soethoudt, Marjolein, Dekker, Niek, Gordon, Euan, van der Stelt, Mario, Heitman, Laura H., van der Es, Daan, IJzerman, Adriaan P.

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1.80 MB

english, 2018

48

Development of a multiplexed activity-based protein profiling assay to evaluate activity of endocannabinoid hydrolase inhibitors

Janssen, Antonius P.A., Van der Vliet, Daan, Bakker, Alexander T., Jiang, Ming, Grimm, Sebastian H., Campiani, Giuseppe, Butini, Stefania, van der Stelt, Mario

Journal:

ACS Chemical Biology

Year:

2018

Language:

english

File:

PDF, 2.27 MB

english, 2018

49

Improving CLL Vγ9Vδ2-T cell fitness for cellular therapy by ex vivo activation and ibrutinib

de Weerdt, Iris, Hofland, Tom, Lameris, Roeland, Endstra, Sanne, Jongejan, Aldo, Moerland, Perry, de Bruin, Renee CG, Remmerswaal, Ester B.M., ten Berge, Ineke J.M., Liu, Nora, van der Stelt, Mario, F

Journal:

Year:

2018

Language:

english

File:

PDF, 1.04 MB

english, 2018

50

Activity-Based Protein Profiling Delivers Selective Drug Candidate ABX-1431, a Monoacylglycerol Lipase Inhibitor, To Control Lipid Metabolism in Neurological Disorders

Jiang, Ming, van der Stelt, Mario

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 328 KB

english, 2018